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Polynucleotides

Polynucleotide Treatments Manchester & Liverpool

Regenerative skin treatments for improved hydration, texture and naturally refreshed-looking skin

Regenerative skin treatments for improved hydration, texture and naturally refreshed-looking skin

Polynucleotides are injectable regenerative treatments designed to support skin quality, hydration and elasticity. They are commonly considered for delicate or ageing areas where the skin may appear tired, crepey, dry or lacking in firmness.

At Jaime Correia Aesthetics, every treatment begins with a personalised consultation and assessment. Your skin, medical history and treatment goals will be carefully reviewed before Jaime recommends whether polynucleotides—or another treatment approach—may be appropriate for you.

Treatments are performed by Jaime Correia, an Advanced Nurse Practitioner and Independent Prescriber with more than 20 years of NHS clinical experience.

What Are Polynucleotides?

Polynucleotides are purified fragments of naturally derived nucleic acids used in injectable skin-rejuvenation treatments. They are intended to support the skin’s natural regenerative processes and may help improve hydration, elasticity, texture and overall skin quality over time.

Unlike conventional dermal fillers, polynucleotides are not primarily used to reshape facial features or create immediate volume. Changes develop gradually as the skin responds to treatment, making them suitable for patients seeking subtle, progressive rejuvenation.

Concerns that may be assessed

  • Tired-looking or crepey under-eye skin

  • Fine lines and early signs of ageing

  • Dry or dehydrated-looking skin

  • Reduced skin elasticity

  • Uneven texture

  • Dull or stressed-looking skin

  • Skin quality around the face and neck

What Can Polynucleotide Treatments Help Improve?

Polynucleotides do not directly correct every type of dark circle, eye bag, hollow or facial line. Your consultation will identify the likely cause of your concern and whether this treatment is appropriate.

Areas That May Be Treated

Polynucleotides do not directly correct every type of dark circle, eye bag, hollow or facial line. Your consultation will identify the likely cause of your concern and whether this treatment is appropriate.

  • Under-eye area

  • Face

  • Cheeks

  • Neck

  • Décolletage

Polynucleotides for the Under-Eye Area

The skin around the eyes is particularly delicate and can become dry, finely lined or crepey over time. Following assessment, polynucleotides may be considered to support hydration and skin quality without creating the volume associated with conventional dermal filler. See my Under-Eye Rejuvenation treatment page.

Polynucleotides versus other treatments

Polynucleotides - Supporting skin quality, hydration and elasticity

Profhilo - Injectable skin remodelling and hydration

Skin Boosters - Improving hydration, texture and radiance

Sculptra - Gradual collagen stimulation and structural rejuvenation

Dermal Fillers - Restoring volume or enhancing facial contours

These treatments are not interchangeable. The most appropriate option depends on your anatomy, skin condition and desired outcome.

When Might I Notice a Difference?

Changes following polynucleotide treatment are gradual rather than immediate. Some patients report progressive improvements in hydration and skin quality over the weeks following treatment. A course may be recommended, followed by maintenance where appropriate. The number and frequency of appointments will be personalised during consultation.

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Individual responses vary, and a specific outcome cannot be guaranteed.

Why Choose Jaime Correia for Polynucleotides ?

  • Advanced Nurse Practitioner

  • Independent Prescriber

  • More than 20 years of NHS experience

  • More than 15 years in facial aesthetics

  • Personalised facial and skin assessment

  • Natural-results philosophy

  • Face-to-face clinical consultation

  • Clear aftercare and follow-up

Polynucleotide Treatment Prices

Prices

Transparent pricing, tailored to your individual treatment plan

Your treatment plan will depend on the area being treated, the product selected and the number of sessions recommended.

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Your recommended plan and complete cost will always be explained before treatment, with no pressure to proceed.

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What is included?

  • A comprehensive medical and facial assessment

  • A personalised treatment plan

  • Treatment performed by an Advanced Nurse Practitioner and Independent Prescriber

  • Guidance on preparation and aftercare

  • Clinical follow-up and ongoing support

 

The number of treatments required varies between patients. Some people may benefit from a course of treatment followed by periodic maintenance, while others may require a different approach. Individual results and treatment requirements vary.

Treatment

  • Polynucleotide Consultation

  • Plinest Face - Single

  • Plinest Face - Course of 3

  • Plinest Eye - Single

  • Plinest Eye- Course of 3

  • Plinest Neck or Decolletes

  • Plinest Neck or Decolletes x3

Price

  • Free

  • £220

  • £600

  • £220

  • £600

  • £220

  • £600

Frequently Asked Questions

What can polynucleotides improve?

Polynucleotides improve skin quality, hydration, firmness, and cellular regeneration from within

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How many treatments might I need?

Most people need an initial course of 2 to 3 sessions of polynucleotides, spaced 2 to 4 weeks apart.

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​How are polynucleotides different from Profhilo or skin boosters?

Polynucleotides repair skin cells at a cellular level, whereas Profhilo and traditional

skin boosters focus primarily on deep hydration and surface-level plumping

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When will I see results from polynucleotides under eyes?

You can expect to see early improvements from under-eye polynucleotides within 2 to 4 weeks, with optimal results appearing 8 to 12 weeks after completing your full course of treatments.

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Is downtime required?

Polynucleotide treatments have minimal downtime, with most visible side effects resolving within 24 to 72 hours.

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Does polynucleotides look natural?

Yes, polynucleotide treatments look very natural because they do not add artificial volume or change your facial shape.

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Can polynucleotides be combined with other treatments?

Yes, polynucleotides can be safely combined with many other aesthetic treatments to improve overall skin quality.

Because polynucleotides work on a cellular level to repair tissue, stimulate collagen, and boost elasticity, they complement treatments that target different aging concerns.

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